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The CrossRoads Clinic Launches Autism Study Using PhosChol

2005-04-29

PHOENIX, AZ --

Crossroads Clinic in Phoenix has begun an IRB approved study designed to determine whether there is a correlation between plasma amino acid levels and intestinal permeability, and if correlation is found, whether levels of specific amino acids might be predictive of response to amino acid supplementation.

The response of autistic children to amino acid supplementation is variable and seemingly unpredictable. Some do extremely well, and some become very agitated, with marked worsening of their autistic symptoms. Many autistic children have extremely poor intestinal function, with chronic yeast infection, dysbiosis, and "leaky gut" being very common.

Our hypothesis is that autistic children with "leaky gut syndrome" will have abnormal levels of essential amino acids in their urine, and that these abnormal levels will correlate with abnormal levels of neurotransmitters. We further hypothesize that the urinary serotonin levels will be most elevated in those children with "leaky gut syndrome". We have a sub-hypothesis that glutamine and glutamate will correlate positively with hyperirritability in these children.

Further study information, participant requirements and protocols can be found by clicking on the link below.

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