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PhosChol: For the Heart
PhosChol’s primary active ingredient is PPC. Clinical studies have shown that PPC can help bring the lipid profile into the normal range. HDL particles containing PPC, transport 50% more cholesterol than native HDL particles. (ZIERENBERG,O. et al: Atherosclerosis 39, 1981, 527) Which Way Do You Prefer to Manage your Cholesterol? PPC activates enzyme systems involved in fat metabolism by mobilizing atherogenic cholesterol from vascular walls and improving disturbances of fat transport. PPC is:
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PhosChol is the Physiological Way to Manage Risk
PhosChol (PPC) interferes at various sites in the pathological processes of dyslipoproteinemia and atherosclerosis by means of its polyunsaturated phosphatidylcholine (PPC) content.
In order to be effective, an anti-hyperlipoproteinemic treatment should act simultaneously on the blood and the vascular walls. The treatment must accordingly aim at improving a pathological lipoprotein pattern as well as reversing existing atherosclerotic changes of the vascular wall. PPC meets this requirement.
PPC restores pathological lipoprotein patterns to normal.
Due to the greater capacity of PPC-enriched HDL (high-density lipoproteins) to take up cholesterol (1), a greater portion of atherogenic cholesterol is converted into a form that can be more readily transported by HDL and which is rapidly metabolized in the liver. By this means, polyunsaturated phosphatidylcholine aids normalization of pathological LDL-cholesterol/HDL-cholesterol ratio, Fig. 1 (2).
PhosChol (PPC) interferes at various sites in the pathological processes of dyslipoproteinemia and atherosclerosis by means of its polyunsaturated phosphatidylcholine (PPC) content.
In order to be effective, an anti-hyperlipoproteinemic treatment should act simultaneously on the blood and the vascular walls. The treatment must accordingly aim at improving a pathological lipoprotein pattern as well as reversing existing atherosclerotic changes of the vascular wall. PPC meets this requirement.
PPC restores pathological lipoprotein patterns to normal.
Due to the greater capacity of PPC-enriched HDL (high-density lipoproteins) to take up cholesterol (1), a greater portion of atherogenic cholesterol is converted into a form that can be more readily transported by HDL and which is rapidly metabolized in the liver. By this means, polyunsaturated phosphatidylcholine aids normalization of pathological LDL-cholesterol/HDL-cholesterol ratio, Fig. 1 (2).
PPC reduces elevated blood lipid levels.
In contrast to several other hypolipidemic agents, PPC helps reduce elevated cholesterol and triglyceride levels, Fig. 2 (3,8).
In contrast to several other hypolipidemic agents, PPC helps reduce elevated cholesterol and triglyceride levels, Fig. 2 (3,8).
PPC improves blood flow properties.
PPC mobilizes cholesterol and facilitates its removal from arterial walls.
- As a physiological substance, PPC is incorporated in the membrane thus increasing flexibility and fluidity of erythrocytes and reducing the tendencies of the red blood cells and platelets to aggregate (7).
- This has the result of reversing an elevated blood viscosity and improving the microcirculation, especially in the capillary bed.
- An appropriate treatment should be maintained continuously for an adequate period only if a minimum risk drug is administered.
- PPC is very well tolerated, even if treatment is extended for a long period of time.
PPC mobilizes cholesterol and facilitates its removal from arterial walls.
- PPC activates the enzyme lecithin: cholesterol-acyltransferase (LCAT) (4). This results in the conversion of more free cholesterol into a cholesterol ester. The high level of linoleic acid contained in PPC induces the formation of cholesterol linoleate which is easier to mobilize and accordingly, less atherogenic.
- The cholesterol linoleate is transported to the liver by HDL and there metabolized and excreted as bile acids with the bile. This is how PPC supports the transport of cholesterol from the periphery to the liver, Fig. 3. In addition, PPC stimulates LCAT activity in the cells of the arterial walls, thus favoring the mobilization of cholesterol and its removal from the arterial wall (6).
References & Areas of UseReferences:
Areas of Use: Dyslipoproteinemia (hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia); atherosclerosis; coronary, cerebral, and peripheral circulatory disturbances; angina pectoris; condition following myocardial infarction, and apoplexy; hypertension due to sclerosis; vascular disorders, especially in diabetes mellitus; nephrotic syndrome; pre-operative treatment for the prevention of thromboembolism.
Dosage and Administration:Unless otherwise prescribed by the physician, 2-3 grams (2-3 capsules or 1 tsp. liquid concentrate) once daily. To be administered during meals with a little liquid if required. For optimal results, split the dose AM - PM.
- Zierenberg, O., et al., Atherosclerosis 39 (1981), 527.
- Zierenberg, O., in: Phospholipids and Atherosclerosis. Raven Press: New York 1983, 175.
- Mastellone, I., et al., J. Nutr. Biochem. 11 (2000), 461.
- Assmann, G,. in: Phosphatidylcholine. Peeters (Ed.) Springer: Berlin 1976, 34.
- Yasugi, T. et al., New Ren Clin. 22. (1973), 691.
- Avogaro, P., in: Phospholipids and Atherosclerosis. Raven Press: New York 1983, 211.
- Schneider, J,. in: Phospholipids and Atherosclerosis. Raven press: New York 1983, 215.
- Zulic, I. et al., Ärztezeitschr. für Naturheilverfahren 39 (1998), 226.
Areas of Use: Dyslipoproteinemia (hypercholesterolemia, hypertriglyceridemia, and hypoalphalipoproteinemia); atherosclerosis; coronary, cerebral, and peripheral circulatory disturbances; angina pectoris; condition following myocardial infarction, and apoplexy; hypertension due to sclerosis; vascular disorders, especially in diabetes mellitus; nephrotic syndrome; pre-operative treatment for the prevention of thromboembolism.
Dosage and Administration:Unless otherwise prescribed by the physician, 2-3 grams (2-3 capsules or 1 tsp. liquid concentrate) once daily. To be administered during meals with a little liquid if required. For optimal results, split the dose AM - PM.
